焦点提醒：PDF下载[1]刘然彬,郝晓地,Mark van Loosdrecht,等.污水风行病学用在新冠肺炎预警研究进展[J].中国给水排水,2021,37(14):37-45.　LIU Ran-bin,HAO Xiao-di,Mark van Loosdrecht,et al.Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic[J].China WatePDF下载[1]刘然彬,郝晓地,Mark van Loosdrecht,等.污水风行病学用在新冠肺炎预警研究进展[J].中国给水排水,2021,37(14):37-45.　LIU Ran-bin,HAO Xiao-di,Mark van Loosdrecht,et al.Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic[J].China Water & Wastewater,2021,37(14):37-45.点击复制污水风行病学用在新冠肺炎预警研究进展中国给水排水[ISSN:1000-4062/CN:12-1073/TU] 卷: 第37卷 期数: 2021年第14期 页码: 37-45 栏目: 出书日期: 2021-07-17Title:Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic作者:刘然彬，郝晓地，Mark van Loosdrecht，江瀚(北京建筑年夜学中-荷将来污水处置手艺研发中间，北京100044)Author(s):LIU Ran-bin,HAO Xiao-di,Mark van Loosdrecht,JIANG Han(Sino-Dutch R & D Centre for Future Wastewater Treatment Technologies, Beijing University of Civil Engineering and Architecture, Beijing 100044, China要害词:新型冠状病毒肺炎; 污水风行病学; 疫情预警; 病毒检测; 核糖核酸Keywords:COVID-19; water-based epidemiology; early warning of epidemic disease; virus detection; RNA摘要:突发新型冠状病毒肺炎（COVID-19）已舒展至全球几近所有国度，累计确诊病例已跨越1亿例。这一全球年夜风行病虽然现阶段在我国多点披发，但已获得根基节制，因为不容乐不雅的全球疫情分散，仍然具有疫情反弹之庞大风险。在新冠疫苗实现年夜范围接种之前，COVID-19爆发有用预警机制仍然是最需要的手艺手段。鉴在传染者粪便/尿液中具有病毒粒子或遗传物资核糖核酸（RNA），荷兰学者提出了基在污水风行病学（WBE）监控SARS-CoV-2（引发COVID-19的病毒）呈现并传布的假想。今朝，污水中SARS-CoV-2无限RNA检测研究成果已证实了这一手艺作为疫情预警的可行性，亦可能按照WBE检测成果表征病毒传布动态与趋向、估算传染群体比例，乃至在必然规模内进行传染群体追踪。在总结WBE手艺在我国成长利用的根本上，对已有污水中SARS-CoV-2的核酸检测研究成果、利用价值和指点意义进行分析阐发，总结WBE研究尺度化方案，辨析亟需深切研究的标的目的范畴。这对我国下一阶段疫情防控具有相当开导与参考价值。Abstract:The New Corona Virus Disease (COVID-19) has spread to almost all countries in the world with the cumulative number of c�����APPonfirmed cases reaching 100 million cases. Although the virus spread has been under control in China with occasional cases reported at this stage, there is still a huge risk of the epidemic rebound due to the external unfavorable situation. Before the virus vaccination covers a large group of people, an effective early warning system of COVID-19 outbreak is still the most needed technical means. In view of the presence of virus particles or genetic material (RNA) in the feces/urine of infected cases, Dutch researcher firstly proposed the idea of monitoring SARS-CoV-2 via wastewater-based epidemiology (WBE). So far, the preliminary studies have proved the feasibility of this technology on SARS-CoV-2 surveillance as an early warning. WBE may also characterize the virus transmission dynamics and trends, estimate the prevalence of infected cases, and even locate the infected cases. The present review firstly summarized the development and application of WBE technology in China. Then, a comprehensive analysis was conducted regarding so far what we know about WBE and what WBE can do for us in terms of SARS-CoV-2 surveillance. Finally, a standard protocol for WBE implementation and the areas for further research were presented. Overall, this work is expected to convey timely information and be a reference for the further epidemic control in China.更新日期/Last Update: 2021-07-19PDF下载[1]刘然彬,郝晓地,Mark van Loosdrecht,等.污水风行病学用在新冠肺炎预警研究进展[J].中国给水排水,2021,37(14):37-45.　LIU Ran-bin,HAO Xiao-di,Mark van Loosdrecht,et al.Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic[J].China Water & Wastewater,2021,37(14):37-45.点击复制

污水风行病学用在新冠肺炎预警研究进展中国给水排水[ISSN:1000-4062/CN:12-1073/TU]卷:第37卷期数:2021年第14期页码:37-45栏目:出书日期:2021-07-17

Title:

Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic

作者:

刘然彬，郝晓地，Mark van Loosdrecht，江瀚

(北京建筑年夜学中-荷将来污水处置手艺研发中间，北京100044)

Author(s):

LIU Ran-bin,HAO Xiao-di,Mark van Loosdrecht,JIANG Han

(Sino-Dutch R & D Centre for Future Wastewater Treatment Technologies, Beijing University of Civil Engineering and Architecture, Beijing 100044, China

要害词:

新型冠状病毒肺炎;污水风行病学;疫情预警;病毒检测;核糖核酸

Keywords:

COVID-19;water-based epidemiology;early warning of epidemic disease;virus detection;RNA

摘要:

突发新型冠状病毒肺炎（COVID-19）已舒展至全球几近所有国度，累计确诊病例已跨越1亿例。这一全球年夜风行病虽然现阶段在我国多点披发，但已获得根基节制，因为不容乐不雅的全球疫情分散，仍然具有疫情反弹之庞大风险。在新冠疫苗实现年夜范围接种之前，COVID-19爆发有用预警机制仍然是最需要的手艺手段。鉴在传染者粪便/尿液中具有病毒粒子或遗传物资核糖核酸（RNA），荷兰学者提出了基在污水风行病学（WBE）监控SARS-CoV-2（引发COVID-19的病毒）呈现并传布的假想。今朝，污水中SARS-CoV-2无限RNA检测研究成果已证实了这一手艺作为疫情预警的可行性，亦可能按照WBE检测成果表征病毒传布动态与趋向、估算传染群体比例，乃至在必然规模内进行传染群体追踪。在总结WBE手艺在我国成长利用的根本上，对已有污水中SARS-CoV-2的核酸检测研究成果、利用价值和指点意义进行分析阐发，总结WBE研究尺度化方案，辨析亟需深切研究的标的目的范畴。这对我国下一阶段疫情防控具有相当开导与参考价值。

Abstract:

The New Corona Virus Disease (COVID-19) has spread to almost all countries in the world with the cumulative number of confirmed cases reaching 100 million cases. Although the virus spread has been under control in China with occasional cases reported at this stage, there is still a huge risk of the epidemic rebound due to the external unfavorable situation. Before the virus vaccination covers a large group of people, an effective early warning system of COVID-19 outbreak is still the most needed technical means. In view of the presence of virus particles or genetic material (RNA) in the feces/urine of infected cases, Dutch researcher firstly proposed the idea of monitoring SARS-CoV-2 via wastewater-based epidemiology (WBE). So far, the preliminary studies have proved the feasibility of this technology on SARS-CoV-2 surveillance as an early warning. WBE may also characterize the virus transmission dynamics and trends, estimate the prevalence of infected cases, and even locate the infected cases. The present review firstly summarized the development and application of WBE technology in China. Then, a comprehensive analysis was conducted regarding so far what we know about WBE and what WBE can do for us in terms of SARS-CoV-2 surveillance. Finally, a standard protocol for WBE implementation and the areas for further research were presented. Overall, this work is expected to convey timely information and be a reference for the further epidemic control in China.

更新日期/Last Update:2021-07-19

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